Role of the nucleus tractus solitarii in the protection of pre-moxibustion on gastric mucosal lesions
Liang Peng
Mi Liu
Xiaorong Chang
Zhou Yang
Shouxiang Yi
Jie Yan
Yan Peng
摘要：Previous studies have shown that somatic sensation by acupuncture and visceral nociceptive stimulation can converge in the nucleus tractus solitarii where neurons integrate signals impact-ing on the function of organs. To explore the role of the nucleus tractus solitarii in the protective mechanism of pre-moxibustion on gastric mucosa, nucleus tractus solitarii were damaged in rats and pre-moxibustion treatment at the Zusanli (ST36) point followed. The gastric mucosa was then damaged by the anhydrous ethanol lavage method. Morphological observations, enzyme linked immunosorbent assays, and western immunoblot analyses showed that gastric mucosa surface lesion and the infiltration of inflammatory cells were significantly ameliorated after pre-moxibustion treatment. Furthermore, the gastric mucosal damage index and somatostatin level were reduced, and epidermal growth factor content in the gastric mucosa and heat-shock protein-70 expression were increased. These results were reversed by damage to the nucleus tractus solitarii. These findings suggest that moxibustion pretreatment at the Zusanli point is protective against acute gastric mucosa injury, and nucleus tractus solitarii damage inhibits these responses. Therefore, the nucleus tractus solitarii may be an important area for regulating the signal transduction of the protective effect of pre-moxibustion on gastric mucosa.
机标关键词：acute gastric mucosa injuryepidermal growth factorgastric mucosal damagesignal transductioninflammatory cellsprotective effectanhydrous ethanol
资助基金：This project was funded by the National Basic Research Program of China(973 Pro-gram)the National Natural Science Foundation of China, (No.81303050,81173326 and 81202770)the Ph.D. Programs Foundation of Ministry of Education of China, (No.20124323110001 and 20124323120002)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 198-204 )
英文信息