Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
Liye Wang
Yuehan Song
Feng Li
Yan Liu
Jie Ma
Meng Mao
Fengzhi Wu
Ying Wu
Sinai Li
Binghe Guan
Xiaolan Liu
摘要：Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medi-cine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang’s pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model es-tablishment. Wen Dan Tang signiifcantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxi-ety may be a result of Wen Dan Tang’s regulation of Ghrelin-Ghrelin receptors.
机标关键词：emotional behaviorsleep deprivationrat model
资助基金：This study was supported by the National Natural Science Youth Foundation in China, (No.81001501)the Natural Science Foundation of Beijing in China, (No.7112071)Beijing University of Chinese Medicine Key Project-Nautical Chinese Medicine in China, (No.522/100604054)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 205-212 )
英文信息