Polysaccharides from Angelica sinensis alleviate neuronal cell injur y caused by oxidative stress
Tao Lei
Haifeng Li
Zhen Fang
Junbin Lin
Shanshan Wang
Lingyun Xiao
Fan Yang
Xin Liu
Junjian Zhang
Zebo Huang
Weijing Liao
摘要：Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a pre-liminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis poly-saccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood lfow after ischemia. Our ifndings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.
机标关键词：oxidative stressneuronal cellsAngelica sinensisreactive oxygen speciesneuroprotective effectsantioxidant activitymembrane potentialcerebral ischemia
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81072917 and 81274048)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 260-267 )
英文信息