Atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inlfammatory and antioxidant effects
Qiuyun Tu
Hui Cao
Wei Zhong
Binrong Ding
Xiangqi Tang
摘要：In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral isch-emia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and super-oxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment signiifcantly inhibited these changes. Our ifndings indicate that atorvastatin protects against ce-rebral ischemia/reperfusion injury through anti-inlfammatory and antioxidant effects.
机标关键词：middle cerebral arterycerebral ischemiacerebral cortex
资助基金：the Natural Science Foundation of Hunan Province in China, (No.11JJ5081)grants from Hunan Provincial Science and Technology Department in China, (No.2012SK3226 and 2011SK3236)the National Natural Science Foudation of China, (No.81271298/H0906)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 268-275 )
英文信息