Can amino-functionalized carbon nanotubes carry functional nerve growth factor?
Wen Chen
Qing Xiong
Quanxia Ren
Yake Guo
Gao Li
摘要：Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent grafting. The physicochemical properties, cytotoxicity to PC12 and chick embryo dorsal root ganglion, and biological activity of the carbon nanotubes-nerve growth factor complexes were investigated. The results showed that amino functionalization improved carbon nanotubes-nerve growth factor complex dispersibility, reduced their toxicity to PC12 cells, and promoted PC12 cell differentiation and chick embryo dorsal root ganglion.
机标关键词：nerve growth factorcarbon nanotubesdorsal root ganglionphysicochemical propertieschick embryocell differentiationbiological activitycell growth
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81160395)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 285-292 )
英文信息