Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer’s disease (Tg2576)
Dongming Yu
Wenjuan Fan
Ping Wu
Jiexin Deng
Jing Liu
Yanli Niu
Mingshan Li
Jinbo Deng
摘要：Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hip-pocampus. The aim of this study was to investigate Cajal-Retzius cells in Alzheimer’s disease pathology. Results revealed that the number of Cajal-Retzius cells markedly reduced with age in both wild type and in mice over-expressing the Swedish double mutant form of amyloid precur-sor protein 695 (transgenic (Tg) 2576 mice). Numerous reelin-positive neurons were positive for activated caspase 3 in Tg2576 mice, suggesting that Cajal-Retzius neuronal loss occurred via apoptosis in this Alzheimer’s disease model. Compared with wild type, the number of Cajal-Ret-zius cells was significantly lower in Tg2576 mice. Western blot analysis confirmed that reelin levels were markedly lower in Tg2576 mice than in wild-type mice. The decline in Cajal-Retzius cells in Tg2576 mice was found to occur concomitantly with the onset of Alzheimer’s disease am-yloid pathology and related behavioral deifcits. Overall, these data indicated that Cajal-Retzius cell loss occurred with the onset and development of Alzheimer’s disease.
机标关键词：wild typedisease modelcell lossform of
资助基金：the National Natural Science Foundation of China, (No.31070952,81071029)the Joint Funds of the NSFC with Henan Provence Government for Fostering Talents, (No. U1204809, and the Henan Province Science Research Project, No.132102310111)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 394-401 )
英文信息