Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson’s disease
Long Teng
Fang Hong
Chenguang Zhang
Jiancheng He
Haiying Wang
摘要：Compound Formula Rehmannia has been shown to be clinically effective in treating Parkin-son’s disease and levodopa-induced dyskinesia;however, the mechanisms remain unclear. In this study, we established a model of Parkinson’s disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson’s disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodo-pa-induced dyskinesia in Parkinson’s disease by modulating neurotransmitter signaling in the corpus striatum.
机标关键词：corpus striatumexcitatory amino acidmRNA expression
资助基金：This study was supported by the National Natural Science Foundation of China, (No.30672684,30973722)Science and Technology Support Traditional Chinese Drug Research and Development Project of Shanghai, (No. F50102)Traditional Chinese Medicine Research Fund of Shanghai Municipal Health Bureau, (No.2012J009A)Annual Research Budget of Shanghai Univer-sity of Traditional Chinese Medicine in 2013, (No.2013JW25)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 407-412 )
英文信息