Apolipoprotein E mimetic peptide protects against diffuse brain injur y
Yaning Zhao
Jianmin Li
Qiqun Tang
Junling Gao
Changxiang Chen
Liwei Jing
Pan Zhang
Shuxing Li
摘要：Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. Howev-er, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apo-lipoprotein E mimetic peptide signiifcantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental ifndings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mito-chondrial apoptotic pathway.
机标关键词：apolipoprotein Ebrain injurysuperoxide dismutase activitylearning and memory functiontherapeutic effectscytochrome c
资助基金：This study was supported by Scientific Research and Development Plan of Hebei Province, (No.20276102D)Key Project of Scientific Research in Universities of Hebei Province in China, (No. ZD2010106)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 463-473 )
英文信息