Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression
Jinhua Fu
Yingjin Zhang
Renrong Wu
Yingjun Zheng
Xianghui Zhang
Mei Yang
Jingping Zhao
Yong Liu
摘要：Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Ad-ministration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results conifrmed that depressive symptoms lessened after treatment with high-dose (150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule signiifcantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effec-tively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain.
机标关键词：rat modelcyclic adenosine monophosphatemedial prefrontal cortexneurotrophic factorsclinical treatmentbinding protein
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81071093,81171268)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 489-497 )
英文信息