Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction
Yanlin Bi
Shuyun Liu
Xinjuan Yu
Mingshan Wang
Yuelan Wang
摘要：Inlfammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophos-phate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-αare involved in inlfammation. Therefore, these inlfammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′adenosine mo-nophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1βand tumor necrosis fac-tor-αwere upregulated and gradually decreased. Therefore, these inlfammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.
机标关键词：protein kinaseaged rats
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 534-539 )
英文信息