Puerarin accelerates neural regeneration after sciatic ner ve injur y
Minfei Wu
Guanjie Zhao
Xiaoyu Yang
Chuangang Peng
Jianwu Zhao
Jun Liu
Rui Li
Zhongli Gao
摘要：Puerarin is a natural isolfavone isolated from plants of the genus Pueraria and functions as a protector against cerebral ischemia. We hypothesized that puerarin can be involved in the repair of peripheral nerve injuries. To test this hypothesis, doses of 10, 5, or 2.5 mg/kg per day puer-arin (8-(β-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) were injected intraperitoneally into mouse models of sciatic nerve injury. Puerarin at the middle and high doses signiifcantly up-regulated the expression of growth-associated protein 43 in the L4-6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling, and reduced the atro-phy of the triceps surae on the affected side and promoted the regeneration of nerve ifbers of the damaged spinal cord at 8 weeks after injury. We conclude that puerarin exerts an ongoing role to activate growth-associated protein 43 in the corresponding segment of the spinal cord after sciat-ic nerve injury, thus contributing to neural regeneration after sciatic nerve injuries.
机标关键词：spinal cordsciatic nervenerve injurycerebral ischemiaperipheral nerve
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81250016)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 589-593 )
英文信息