Rapamycin promotes Schwann cell migration and nerve growth factor secretion
Fang Liu
Haiwei Zhang
Kaiming Zhang
Xinyu Wang
Shipu Li
Yixia Yin
摘要：Rapamycin, similar to FK506, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of rapamycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration (1.53 nmol/L) more signiifcantly promoted Schwann cell migration than the highest FK506 concentration (100μmol/L). Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not signiifcantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.
机标关键词：nerve growth factorsperipheral nerve regenerationpotential applicationcell proliferationcell migrationSchwann cellsin vitro
资助基金：the National Natural Science Foundation of China, (No.51172171 and 51103112)the Key Project of Chinese Ministry of Education, (No.313041)the Natural Science Foundation of Hubei Province, (No.2013CFB354)2013-IV-099(No. WUT)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 602-609 )
英文信息