APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer’s disease
Qin Zhou
Dantao Peng
Xinrui Yuan
Zeping Lv
Shenghang Pang
Wenyu Jiang
Chuyu Yang
Xiaohong Shi
Guofang Pang
Yige Yang
Haiqun Xie
Wandong Zhang
Caiyou Hu
Ze Yang
摘要：Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer’s disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer’s disease patients. We performed a 30-month longitudi-nal cohort study to investigate the relationship between Alzheimer’s disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer’s disease were recruit-ed form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess pa-tients’ cognitive function. After a 30-month follow-up period, we found a signiifcant reduction in Mini-Mental State Examination total score, a higher proportion of patients fuliflling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOEε4 carriers compared with non-carriers. In addition, the APOEε4 allele frequency was signiifcantly higher in the cognitive impairment progression group compared with the non-cognitive im-pairment progression group. In conclusion, APOEε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOEε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer’s disease.
机标关键词：Chinese patientslow density lipoproteingenetic polymorphismsDementia Rating Scaleapolipoprotein Eallele frequencycohort study
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81370445,81061120527,81241082)Major Funding from Beijing Hospital, (No. BJ-2010-30)Key Project of Clinical Disciplines at the Subordinate Hospital, Ministry of Health, (No.10120101)Na-tional Department Public Benefit Research Foundation by the Ministry of Health, (No.201302008)12th 5-year National Program from Ministry of Scientific Technology, (No.2012BAI10B01)Science and Technology Development Foundation of Guangxi Zhuang Autonomous Region, (No.1355005-6-2)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 653-660 )
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