Acrolein as a novel therapeutic target for motor and sensor y deifcits in spinal cord injur y
Jonghyuck Park
Breanne Muratori
Riyi Shi
摘要：In the hours to weeks following traumatic spinal cord injuries (SCI), biochemical processes are initiated that further damage the tissue within and surrounding the initial injury site:a process termed secondary injury. Acrolein, a highly reactive unsaturated aldehyde, has been shown to play a major role in the secondary injury by contributing signiifcantly to both motor and sensory deif-cits. In particular, efforts have been made to elucidate the mechanisms of acrolein-mediated dam-age at the cellular level and the resulting paralysis and neuropathic pain. In this review, we will highlight the recent developments in the understanding of the mechanisms of acrolein in motor and sensory dysfunction in animal models of SCI. We will also discuss the therapeutic beneifts of using acrolein scavengers to attenuate acrolein-mediated neuronal damage following SCI.
机标关键词：spinal cord injuriessensory dysfunctionneuropathic painanimal models
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 677-683 )
英文信息