3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia
Wanhong Zhao
Chao Luo
Jue Wang
Jian Gong
Bin Li
Yingxia Gong
Jun Wang
Hanqin Wang
摘要：3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study li-gated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphtha-lide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby im-proving cerebral neuronal injury and cognitive deifcits.
机标关键词：cerebral ischemianeuronal injurycholine acetyltransferasecognitive functionoxidative stresscarotid arteriesischemic strokecerebral cortex
资助基金：This study was financially supported by Innovation Team Project of Hubei Province 2011 Plans, (No.2011JH-2013CXTT06)Momentous Scientific Research Funds of Hubei Provincial Educa-tion Ministry, (No. D20102101)Cultivating Funds of Country’s Projects of Hubei University of Medicine, (No.2013GPY03)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 719-726 )
英文信息