Upregulation of Nogo receptor expression induces apoptosis of retinal ganglion cells in diabetic rats
Xuezheng Liu
Zhongfu Zuo
Wanpeng Liu
Zhiyun Wang
Yang Hou
Yunjie Fu
Yuzhi Han
摘要：The Nogo receptor is an essential factor for neuronal apoptosis, but the changes in Nogo receptor expression in the retina and the effects of the Nogo receptor on retinal ganglion cell apoptosis in diabetes mellitus remain unclear. We found that Nogo receptor expression was mainly visible in retinal ganglion cells of a rat model of diabetes mellitus induced by streptozotocin. At 12 weeks after onset of diabetes mellitus, Nogo receptor and Rho kinase expression signiifcantly increased in the retina, and retinal ganglion cell apoptosis was apparent. When RNA interference was used to suppress Nogo receptor expression in rat retina, Rho kinase expression was obviously inhibit-ed, and retinal ganglion cell apoptosis was evidently reduced in rats with diabetes mellitus. These results indicate that upregulation of Nogo receptor expression is an important mechanism of retinal ganglion cell apoptosis in rats with diabetes mellitus.
机标关键词：diabetic ratsdiabetes mellituscell apoptosisretinal ganglion cellsRho kinaseneuronal apoptosisRNA interferencerat model
资助基金：This study was supported by the National Natural Science Foundation of China, (No.31140072,81300931)the Liaoning Provincial Department of Science and Technology Project, (No.2011225015)the Natural Science Foundation of Liaoning Province in China, (No.2013022055)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 815-820 )
英文信息