Potential risk of mitomycin Cat high concentrations on peripheral nerve structure
Tao Sui
Jinhong Zhang
Shihao Du
Changhui Su
Jun Que
Xiaojian Cao
摘要：Although the local application of mitomycin C may prevent epidural adhesion after laminectomy, mitomycin C can induce neurotoxicity in optic and acoustic nerves at high concentrations. To determine the safe concentration range for mitomycin C, cotton pads soaked with mitomycin C at different concentrations (0.1, 0.3, 0.5, and 0.7 mg/mL) were immediately applied for 5 minutes to the operation area of rats that had undergone laminectomy at L1. Rat sciatic nerves, instead of dorsal nerves, were used in this study. The results showed that mitomycin C at 0.1-0.5 mg/mL did not damage the structure and function of the sciatic nerve, while at 0.7 mg/mL, mitomycin C signiifcantly reduced the thickness of the sciatic nerve myelin sheath compared with lower concen-trations, though no functional change was found. These experimental ifndings indicate that the local application of mitomycin C at low concentrations is safe to prevent scar adhesion following laminectomy, but that mitomycin C at high concentrations (>0.7 mg/mL) has potential safety risks to peripheral nerve structures.
机标关键词：mitomycin Csciatic nervesstructure and functionperipheral nervemyelin sheathused in
资助基金：the National Natural Science Foundation of China, (No.81171694,81201374,81371968,81371969)the Nature Science Foundation of Jiangsu Province (No. BK2012718, BK2011844)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 821-827 )
英文信息