Similar effects of substance P on learning and memory function between hippocampus and striatal marginal division
Yan Yu
Changchun Zeng
Siyun Shu
Xuemei Liu
Chuhua Li
摘要：Substance P is an endogenous neurokinin that is present in the central and peripheral nervous systems. The neuropeptide substance P and its high-afifnity receptor neurokinin 1 receptor are known to play an important role in the central nervous system in inlfammation, blood pressure, motor behavior and anxiety. The effects of substance P in the hippocampus and the marginal di-vision of the striatum on memory remain poorly understood. Compared with the hippocampus as a control, immunolfuorescence showed high expression of the substance P receptor, neuro-kinin 1, in the marginal division of the striatum of normal rats. Unilateral or bilateral injection of an antisense oligonucleotide against neurokinin 1 receptor mRNA in the rat hippocampus or marginal division of the striatum effectively reduced neurokinin 1 receptor expression. Indepen-dent of injection site, rats that received this antisense oligonucleotide showed obviously increased footshock times in a Y-maze test. These results indicate that the marginal division of the striatum plays a similar function in learning and memory to the hippocampus, which is a valuable addi-tion to our mechanistic understanding of the learning and memory functions of the marginal division of the striatum.
机标关键词：learning and memory functionsantisense oligonucleotidesubstance Pcentral nervous system
资助基金：the National Natural Science Foundation of China, (No.30600797,30873238)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 857-863 )
英文信息