Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
Fatemeh Anbari
Mohammad Ali Khalili
Ahmad Reza Bahrami
Arezoo Khoradmehr
Fatemeh Sadeghian
Farzaneh Fesahat
Ali Nabi
摘要：To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intrave-nous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and ad-ministered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significant-ly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.
机标关键词：traumatic brain injurymarrow mesenchymal stem cellscerebral cortexnerve cellscell transplantationimpact accelerationrat model
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 919-923 )
英文信息