Acupuncture and moxibustion reduces neuronal edema in Alzheimer’s disease rats
Hua Zhou
Guojie Sun
Lihong Kong
Yanjun Du
Feng Shen
Shuju Wang
Bangguo Chen
Xiaoling Zeng
摘要：To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer’s disease, we established a rat model of Alzheimer’s disease and measured axin andβ-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacu-puncture, or both, at Baihui (GV20) and Shenshu (BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuro-protective effect of acupuncture and moxibustion in Alzheimer’s disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway.
机标关键词：signal transduction pathwayacupuncture and moxibustionrat model
资助基金：the National Natural Science Foundation of China, (No.30772837)the Wuhan Municipal “Morning Sun” Science and Technology Plan, (No.200850731347)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 968-972 )
英文信息