L-carnitine alleviates sciatic nerve crush injury in rats:functional and electron microscopy assessments
ümmü Zeynep Avsar
Umit Avsar
Ali Aydin
Muhammed Yayla
Berna Ozturkkaragoz
Harun Un
Murat Saritemur
Tolga Mercantepe
摘要：Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuro-protective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved signiifcantly. These ifndings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.
机标关键词：crush injurysciatic nerveneuroprotective effectsdiabetes mellitus
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1020-1024 )
英文信息