Attenuated inhibition of medium spiny neurons participates in the pathogenesis of childhood depression
Dandan Liu
Linghan Hu
Junqi Zhang
Ping Zhang
Shengtian Li
摘要：Accumulating evidence suggests that the nucleus accumbens, which is involved in mechanisms of reward and addiction, plays a role in the pathogenesis of depression and in the action of anti-depressants. In the current study, intraperitoneal injection of nomifensine, a dopamine reuptake inhibitor, decreased depression-like behaviors in the Wistar Kyoto rat model of depression in the sucrose-preference and forced swim tests. Nomifensine also reduced membrane excitability in medium spiny neurons in the core of the nucleus accumbens in the childhood Wistar Kyoto rats as evaluated by electrophysiological recording. In addition, the expression of dopamine D2-like receptor mRNA was downregulated in the nucleus accumbens, striatum and hippocampus of nomifensine-treated childhood Wistar Kyoto rats. These experimental ifndings indicate that impaired inhibition of medium spiny neurons, mediated by dopamine D2-like receptors, may be involved in the formation of depression-like behavior in childhood Wistar Kyoto rats, and that nomifensine can alleviate depressive behaviors by reducing medium spiny neuron membrane excitability.
机标关键词：nucleus accumbensrat model
资助基金：This study was supported by the National Natural Science Foundation of China, (No.31271198 and 81121001)grants from the Shanghai Committee of Science and Technology, (No.11ZR1415900)the State Key Laboratory of Medical Neurobiology, Fudan University, (No.10-12)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1079-1088 )
英文信息