Melatonin reduces traumatic brain injur y-induced oxidative stress in the cerebral cortex and blood of rats
Nilgnenol
Mustafa Nazrolu
摘要：Free radicals induced by traumatic brain injury have deleterious effects on the function and antioxidant vitamin levels of several organ systems including the brain. Melatonin possesses antioxidant effect on the brain by maintaining antioxidant enzyme and vitamin levels. We in-vestigated the effects of melatonin on antioxidant ability in the cerebral cortex and blood of traumatic brain injury rats. Results showed that the cerebral cortex β-carotene, vitamin C, vita-min E, reduced glutathione, and erythrocyte reduced glutathione levels, and plasma vitamin C level were decreased by traumatic brain injury whereas they were increased following melatonin treatment. In conclusion, melatonin seems to have protective effects on traumatic brain inju-ry-induced cerebral cortex and blood toxicity by inhibiting free radical formation and supporting antioxidant vitamin redox system.
机标关键词：cerebral cortextraumatic brain injuryreduced glutathionevitamin Cprotective effectsantioxidant enzymefree radical
资助基金：Isparta Turkey (http.//www.cmos.org. tr/2014/)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1112-1116 )
英文信息