Neuroprotective effect of ischemic preconditioning in focal cerebral infarction:relationship with upregulation of vascular endothelial growth factor
Yong Liu
Suiqiang Zhu
Yunfu Wang
Jingquan Hu
Lili Xu
Li Ding
Guangjian Liu
摘要：Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic pre-conditioning in rats by simulating a transient ischemic attack twice (each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction (2 hour occlusion-reper-fusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was signiifcantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascu-lar endothelial growth factor.
机标关键词：cerebral infarctionischemic preconditioningendothelial growth factortransient ischemic attackneuroprotective effectmiddle cerebral arteryprotective effects
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1117-1121 )
英文信息