Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injur y in aged rats
Xiangyu Ji
Lina Zhang
Ran Liu
Yingzhi Liu
Jianfang Song
He Dong
Yanfang Jia
Zangong Zhou
摘要：Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our exper-imental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral isch-emia-reperfusion injury.
机标关键词：aged ratscerebral ischemiacell apoptosisneuronal apoptosisenergy metabolismthe aged
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1122-1128 )
英文信息