Quercetin alleviates high glucose-induced Schwann cell damage by autophagy
Ling Qu
Xiaochun Liang
Bei Gu
Wei Liu
摘要：Quercetin can reverse high glucose-induced inhibition of neural cell proliferation, and therefore may have a neuroprotective effect in diabetic peripheral neuropathy. It is dififcult to obtain pri-mary Schwann cells and RSC96 cells could replace primary Schwann cells in studies of the role of autophagy in the mechanism underlying diabetic peripheral neuropathy. Here, we show that under high glucose conditions, there are fewer autophagosomes in immortalized rat RSC96 cells and primary rat Schwann cells than under control conditions, the proliferative activity of both cell types is signiifcantly impaired, and the expression of Beclin-1 and LC3, the molecular mark-ers for autophagy, is signiifcantly lower. After intervention with quercetin, the autophagic and proliferative activity of both cell types is rescued. These results suggest that quercetin can allevi-ate high glucose-induced damage to Schwann cells by autophagy.
机标关键词：diabetic peripheral neuropathySchwann cellsproliferative activityhigh glucoseneuroprotective effectcell proliferation
资助基金：This study was supported by the National Natural Science Foundation of China, (No.30572438)the Beijing Science Nuture Foundation, (No.7132189)a grant from Science Foundation of Peking Union Medical College Hospital, (No.2013-098)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1195-1203 )
英文信息