Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
Peng Yan
Xiaohong Yang
Xiaoyu Yang
Weidong Zheng
Yunbing Tan
摘要：Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root re-mains unclear, and needs further investigation. In this study, a complete spinal cord injury model was established in New Zealand white rabbits through T9-10 segment transection. Rabbits were given continuous electrical stimulation for a short period and then chronic stimulation for a longer period. Results showed that compared with normal rabbits, the structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimu-lation. There was no signiifcant difference in the expression of apoptosis-related proteins such as Bax, Caspase-3, and Bcl-2. Experimental ifndings indicate that neurons in the rabbit sacral nerve roots tolerate electrical stimulation, even after long-term anode block electrical stimulation.
机标关键词：sacral nerveelectrical stimulationspinal cord injuryNew Zealand white rabbitsnerve rootbladder functionnerve cells
资助基金：Funding(No.20100735)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1217-1221 )
英文信息