Diffuse axonal injury after traumatic cerebral microbleeds：an evaluation of imaging techniques
Jun Liu
Zhifeng Kou
Yongquan Tian
摘要：Previous neuropathological studies regarding traumatic brain injury have primarily focused on changes in large structures, for example, the clinical prognosis after cerebral contusion, intrace-rebral hematoma, and epidural and subdural hematoma. In fact, many smaller injuries can also lead to severe neurological disorders. For example, cerebral microbleeds result in the dysfunc-tion of adjacent neurons and the disassociation between cortex and subcortical structures. These tiny changes cannot be adequately visualized on CT or conventional MRI. In contrast, gradient echo sequence-based susceptibility-weighted imaging is very sensitive to blood metabolites and microbleeds, and can be used to evaluate traumatic cerebral microbleeds with high sensitivity and accuracy. Cerebral microbleed can be considered as an important imaging marker for dif-fuse axonal injury with potential relevance for prognosis. For this reason, based on experimental and clinical studies, this study reviews the role of imaging data showing traumatic cerebral mi-crobleeds in the evaluation of cerebral neuronal injury and neurofunctional loss.
机标关键词：traumatic brain injuryneurological disordershigh sensitivityneuronal injury
资助基金：the Hunan Provincial Science and Technology Department, (No.2009FJ3092)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1222-1230 )
英文信息