Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats
Bin Liu
Jing Tang
Jinxia Zhang
Shiying Li
Min Yuan
Ruimin Wang
摘要：It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuro-nal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-oper-ated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results conifrm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects.
机标关键词：vascular dementiaintraperitoneal injectionneuroprotective effectsneuronal injuryrat model
资助基金：This study was supported by the Scientific Technology Research Project of Hebei Provincial Higher Learning Schools in China, (No. ZH2012046)the Major Medical Research Program of Hebei Province in China, (No. ZD2013087)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1288-1296 )
英文信息