Strategies for myelin regeneration：lessons learned from development
Abhay Bhatt
Lir-Wan Fan
Yi Pang
摘要：Myelin regeneration is indispensably important for patients suffering from several central nervous system (CNS) disorders such as multiple sclerosis (MS) and spinal cord injury (SCI), because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understanding the cellular and molecular mechanisms underlying re-myelination is critical for the development of remyelination-speciifc therapeutic approaches. As remyelination shares certain common mechanisms with developmental myelination, knowledge from study of developmental myelination contributes greatly to emerging myelin regeneration therapies, best evidenced as the recently developed human anti-Nogo receptor interacting pro-tein-1 (LINGO-1) monoclonal antibodies to treat MS patients in clinical trials.
机标关键词：central nervous systemmolecular mechanismsspinal cord injurymultiple sclerosisclinical trials
资助基金：The work is supported by grants from NIH(R01NS080844)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1347-1350 )
英文信息