An inside-out vein graft iflled with platelet-rich plasma for repair of a short sciatic nerve defect in rats
Ji Yeong Kim
Woo Joo Jeon
Dong Hwee Kim
Im Joo Rhyu
Young Hwan Kim
Inchan Youn
Jong Woong Park
摘要：Platelet-rich plasma containing various growth factors can promote nerve regeneration. An in-side-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft iflled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft iflled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft iflled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft iflled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.
机标关键词：sciatic nervevein graftnerve functionnerve regenerationgrowth factorsmyelin sheath
资助基金：This study was supported by Basic Science Research Program through the National Re-search Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, (No.2011-0010429)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1351-1357 )
英文信息