Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells
Yuan Liu
Yueling Zhang
Zhaohui Gu
Lina Hao
Juan Du
Qian Yang
Suping Li
Liying Wang
Shilei Gong
摘要：Although cholecystokinin octapeptide-8 is important for neurological function, its neuropro-tective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspa-se-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epi-thelial cells against apoptosis induced by peroxynitrite.
机标关键词：epithelial cellsoxidative stressoxidative injury
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1402-1408 )
英文信息