Integration of animal behaviors under stresses with different time courses
Lun Zheng
Xigeng Zheng
摘要：We used animal models of“forced swim stress”and“chronic unpredictable stress”, and tried to reveal whether a passive coping style of high lfotation behavior in forced swim stress predicts an-hedonia behavior after chronic unpredictable stress, and whether the dopamine system regulates lfoating and anhedonia behaviors. Our results conifrmed that depression-prone rats use“lfoating behavior”as a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress. Intraperitoneal injection or nucleus accumbens microin-jection of the dopamine 2/3 receptor subtype agonist ropinirole reduced lfoating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. These data indicate that lfoating behavior is a defensive mode that is preferred by susceptible individ-uals under conditions of acute stress. Simultaneously, these animals more readily experienced anhedonia under long-term stress;that is, they were more readily affected by depression. Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in lfoating behaviors and anhedonia.
机标关键词：chronic unpredictable stressnucleus accumbenscoping strategyanimal models
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1464-1473 )
英文信息