The biochemical pathways of central nervous system neural degeneration in niacin deifciency
Linshan Fu
Venkatesh Doreswamy
Ravi Prakash
摘要：Neural degeneration is a very complicated process. In spite of all the advancements in the mo-lecular chemistry, there are many unknown aspects of the phenomena of neurodegeneration which need to be put together. It is a common sequela of the conditions of niacin deifciency. Neural degeneration in Pellagra manifests as chromatolysis mainly in pyramidal followed by other neurons and glial cells. However, there is a gross lack of understanding of biochemi-cal mechanisms of neurodegeneration in niacin deifciency states. Because of the necessity of niacin or its amide derivative NAD in a number of biochemical pathways, it is understandable that several of these pathways may be involved in the common outcome of neural degener-ation. Here, we highlight ifve pathways that could be involved in the neuraldegeneration for which evidence has accumulated through several studies. These pathways are:1) the trypto-phan-kyneurenic acid pathway, 2) the mitochondrial ATP generation related pathways, 3) the poly (ADP-ibose) polymerase (PARP) pathway, 4) the BDNF-TRKB Axis abnormalities, 5) the genetic inlfuences of niacin deifciency.
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论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1509-1513 )
英文信息