Effects of naringin, a lfavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain
Un Ju Jung
Sang Ryong Kim
摘要：Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson’s disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson’s disease with anti-inlfammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson’s disease.
机标关键词：dopaminergic neuronsneurotrophic factorglial cellcitrus fruits
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1514-1517 )
英文信息