Tooth loss inhibits neurogenesis in the dentate gyrus of adult mice
Shaochen Su
Tao Qi
Baoli Su
Huibin Gu
Jianlin Wang
Lan Yang
摘要：Tooth loss has been shown to affect learning and memory in mice and increases the risk of Alz-heimer’s disease. The dentate gyrus is strongly associated with cognitive function. This study hypothesized that tooth loss affects neurons in the dentate gyrus. Adult male mice were random-ly assigned to either the tooth loss group or normal control group. In the tooth loss group, the left maxillary and mandibular molars were extracted. Normal control mice did not receive any intervention. Immunolfuorescence staining revealed that the density and absorbance of double-cortin-and neuronal nuclear antigen-positive cells were lower in the tooth loss group than in the normal control group. These data suggest that tooth loss may inhibit neurogenesis in the dentate gyrus of adult mice.
机标关键词：dentate gyruslearning and memorycognitive functionmale mice
资助基金：This study was supported by the Science and Technology Key Project of Ministry of Educa-tion of China, (No.106152)the Scientific Research Project of Second Hospital of Lanzhou University of China, (No. C1708)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1606-1609 )
英文信息