Damage of hippocampal neurons in rats with chronic alcoholism
Ailin Du
Hongbo Jiang
Lei Xu
Na An
Hui Liu
Yinsheng Li
Ruiling Zhang
摘要：Chronic alcoholism can damage the cytoskeleton and aggravate neurological deifcits. However, the effect of chronic alcoholism on hippocampal neurons remains unclear. In this study, a model of chronic alcoholism was established in rats that were fed with 6%alcohol for 42 days. Endog-enous hydrogen sulifde content and cystathionine-beta-synthase activity in the hippocampus of rats with chronic alcoholism were signiifcantly increased, while F-actin expression was decreased. Hippocampal neurons in rats with chronic alcoholism appeared to have a fuzzy nuclear mem-brane, mitochondrial edema, and ruptured mitochondrial crista. These findings suggest that chronic alcoholism can cause learning and memory decline in rats, which may be associated with the hydrogen sulfide/cystathionine-beta-synthase system, mitochondrial damage and reduced expression of F-actin.
机标关键词：hippocampal neuronslearning and memoryhydrogen sulfide
资助基金：the National Natural Science Foundation of China, (No.81471351)Key Project of the Science and Technology Foundation of Henan Provincial Education Department of China, (No.12A320013)the Funds of Henan Province Health Technology Talents Innovative Project, (No.3052)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1610-1615 )
英文信息