Methylmercury chloride damage to the adult rat hippocampus cannot be detected by proton magnetic resonance spectroscopy
Zhiyan Lu
Jinwei Wu
Guangyuan Cheng
Jianying Tian
Zeqing Lu
Yongyi Bi
摘要：Previous studies have found that methylmercury can damage hippocampal neurons and accord-ingly cause cognitive dysfunction. However, a non-invasive, safe and accurate detection method for detecting hippocampal injury has yet to be developed. This study aimed to detect methylmer-cury-induced damage on hippocampal tissue using proton magnetic resonance spectroscopy. Rats were given a subcutaneous injection of 4 and 2 mg/kg methylmercury into the neck for 50 consecutive days. Water maze and pathology tests confirmed that cognitive function had been impaired and that the ultrastructure of hippocampal tissue was altered after injection. The results of proton magnetic resonance spectroscopy revealed that the nitrogen-acetyl aspartate/creatine, choline complex/creatine and myoinositol/creatine ratio in rat hippocampal tissue were unchanged. Therefore, proton magnetic resonance spectroscopy can not be used to determine structural damage in the adult rat hippocampus caused by methylmercury chloride.
机标关键词：magnetic resonancehippocampal neuronscognitive functionstructural damagedetection method
资助基金：This study was supported by the National Natural Science Foundation of China, (No.81060231,81160338)Hubei Province Natural Science Foundation of China, (No.2013CFB277)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 1616-1620 )
英文信息