Decorin treatment of spinal cord injury
Maryam Esmaeili
Martin Berry
Ann Logan
Zubair Ahmed
摘要：The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived ifbroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory mole-cules ifll the lesion site providing both a physical and chemical barrier to regenerating axons. Dec orin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-ifbrotic and anti-inlfammatory and attenu-ates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.
机标关键词：central nervous system
资助基金：the Wellcome Trust, grant (No.092539/Z/10/Z and the International Spinal Research Trust, grant No. STR103. AL is also funded by the National Institute for Health research (NIHR) Surgical Reconstruction and Microbiology Research Centr)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1653-1656 )
英文信息