Craniocerebral injury promotes the repair of peripheral ner ve injur y
Wei Wang
Jun Gao
Lei Na
Hongtao Jiang
Jingfeng Xue
Zhenjun Yang
Pei Wang
摘要：The increase in neurotrophic factors after craniocerebral injury has been shown to promote fracture healing. Moreover, neurotrophic factors play a key role in the regeneration and repair of peripheral nerve. However, whether craniocerebral injury alters the repair of peripheral nerve injuries remains poorly understood. Rat injury models were established by transecting the left sciatic nerve and using a free-fall device to induce craniocerebral injury. Compared with sciat-ic nerve injury alone after 6-12 weeks, rats with combined sciatic and craniocerebral injuries showed decreased sciatic functional index, increased recovery of gastrocnemius muscle wet weight, recovery of sciatic nerve ganglia and corresponding spinal cord segment neuron mor-phologies, and increased numbers of horseradish peroxidase-labeled cells. These results indicate that craniocerebral injury promotes the repair of peripheral nerve injury.
机标关键词：craniocerebral injuryperipheral nerve injuryneurotrophic factorssciatic nervefracture healingspinal cord
资助基金：hTis study was supported by a grant from Hebei Provincial Science and Technology De-partment in China, (No.142777105D,13277772D)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1703-1708 )
英文信息