Edaravone promotes functional recover y after mechanical peripheral nerve injury
Teng Zhang
Zhengwei Li
Jianli Dong
Feng Nan
Tao Li
Qing Yu
摘要：Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic functional index and superoxide dismutase activity of the sciatic nerve were increased, and the malondialdehyde level was decreased in animals in the edaravone group compared with those in the model group. Bcl-2 expression was increased, but Bax expres-sion was decreased in anterior horn cells of the L4-6 spinal cord segments. These results indicated that edaravone has a neuroprotective effect following peripheral nerve injury caused by mechan-ical factors through alleviating free radical damage to cells and inhibiting lipid peroxidation, as well as regulating apoptosis-related protein expression.
机标关键词：peripheral nerve injurysuperoxide dismutase activitysciatic nerveneuroprotective effectfree radical damagetherapeutic effectprotein expressionlipid peroxidation
资助基金：This study was supported by the National Natural Science Foundation of China, (No.30901515)Dalian Municipal Science and Technology Project Foundation in China, (No.2009J22DW029)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1709-1715 )
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