Neurotrophic factors：from neurodevelopmental regulators to novel therapies for Parkinson’s disease
Shane V. Hegarty
Gerard W. O’Keeffe
Aideen M. Sullivan
摘要：Neuroprotection and neuroregeneration are two of the most promising disease-modifying ther-apies for the incurable and widespread Parkinson’s disease. In Parkinson’s disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neu-rotrophic factors play important regulatory roles in the development, survival and maintenance of speciifc neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson’s disease. Several neurotrophic fac-tors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.
机标关键词：dopaminergic neuronstherapeutic potentialneurotrophic factorsslow down
资助基金：Studies in the authors’ laboratories are supported by grants from the Irish Research Coun-cil(R13702 and R15897)Studies in the authors’ laboratories are supported by grants from the Irish Research Coun-cil( SVH/AS/G’OK)the Health Research Board of Ireland(HRA/2009/127)the Health Research Board of Ireland(GO’K/AS)Science Foundation Ireland(10/RFP/NES2786)Science Foundation Ireland( GO’K)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1708-1711 )
英文信息