Impact of vasculature damage on the outcome of spinal cord injury：a novel collagenase-induced model may give new insights into the mechanisms involved
Patrick Losey
Daniel C. Anthony
摘要：The deleterious effect of vasculature damage on the outcome of spinal cord injury has long been recognized, and numerous clinical studies have shown that the presence of hemorrhage into the spinal cord is directly associated with a poorer neurological outcome. Vascular damage leads to de-creased blood lfow to the cord and the release of potentially toxic blood-borne components. Here we consider the mechanisms that may be contributing to hemorrhage-induced damage and discuss the utility of a new model of spinal cord hemorrhage, which was urgently required as most of our current understanding has been extrapolated from intracerebral hemorrhage studies.
机标关键词：spinal cord injuryintracerebral hemorrhagenew model
资助基金：Funding(No. MRCG0300456)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1783-1786 )
英文信息