Three-dimensional conformal intensity-modulated radiation therapy of left femur foci does not damage the sciatic nerve
Wanlong Xu
Xibin Zhao
Qing Wang
Jungang Sun
Jiangbo Xu
Wenzheng Zhou
Hao Wang
Shigui Yan
Hong Yuan
摘要：During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra-diotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subjected to radio-therapy (40 Gy) for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no ob-vious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized withEchinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized withEchi-nococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease inMeriones meridiani without damaging the morphology or function of the sciatic nerve.
机标关键词：sciatic nerveradiation therapydehydrogenase activitytherapeutic effectscell structure
资助基金：Funding(No.81360276)a grant from the Science and Technology Project of Xinjiang Uygur Autonomous Region in China, (No.2013911129)a grant from the Youth Science and Technology Innovation Talents Proj-ect of Xinjiang Uygur Autonomous Region-Young Doctor Talents Training Project, (No.2013731013)the Natural Science Foundation of Xinjiang Uygur Autonomous Region, (No.2012211B34)the China Postdoctoral Science Foundation, (No.2014M552566XB)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1824-1829 )
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