Meta analysis of olfactory ensheathing cell transplantation promoting functional recovery of motor nerves in rats with complete spinal cord transection
Jun Liu
Ping Chen
Qi Wang
Yu Chen
Hailong Yu
Junxiong Ma
Mingming Guo
Meihui Piao
Weijian Ren
Liangbi Xiang
摘要：OBJECTIVE:To evaluate the effects of olfactory ensheathing cell transplantation on functional recovery of rats with complete spinal cord transection. DATA SOURCES:A computer-based online search of Medline (1989-2013), Embase (1989-2013), Cochrane library (1989-2013), Chinese Biomedical Literature Database (1989-2013), China National Knowledge Infrastructure (1989-2013), VIP (1989-2013), Wanfang databases (1989-2013) and Chinese Clinical Trial Register was conducted to collect randomized controlled trial data regarding olfactory ensheathing cell transplantation for the treatment of complete spinal cord transection in rats. SELECTION CRITERIA: Randomized controlled trials investigating olfactory ensheathing cell transplantation and other transplantation methods for promoting neurological functional recov-ery of rats with complete spinal cord transection were included in the analysis. Meta analysis was conducted using RevMan 4.2.2 software. MAIN OUTCOME MEASURES: Basso, Beattie and Bresnahan scores of rats with complete spinal cord transection were evaluated in this study. RESULTS: Six randomized controlled trials with high quality methodology were included. Meta analysis showed that Basso, Beattie and Bresnahan scores were signiifcantly higher in the olfacto-ry ensheathing cell transplantation group compared with the control group (WMD= 3.16, 95%CI (1.68, 4.65);P < 0.00001). CONCLUSION:Experimental studies have shown that olfactory ensheathing cell transplantation can promote the functional recovery of motor nerves in rats with complete spinal cord transection.
机标关键词：spinal cordcell transplantationrandomized controlled trialsClinical Trialhigh qualitymethods for
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1850-1858 )
英文信息