Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake
Xijin Wang
Meihua Wang
Liu Yang
Jie Bai
Zhiqiang Yan
Yuhong Zhang
Zhenguo Liu
摘要：Impaired iron homeostasis may cause damage to dopaminergic neurons and is critically involved in the pathogenesis of Parkinson’s disease. At present, very little is understood about the effect of neonatal iron intake on behavior in aging animals. Therefore, we hypothesized that increased neonatal iron intake would result in signiifcant behavior abnormalities and striatal dopamine depletion during aging, and Sirtuin 2 contributes to the age-related neurotoxicity. In the present study, we observed that neonatal iron intake (120 μg/g per day) during postnatal days 10–17 resulted in significant behavior abnormalities and striatal dopamine depletion in aging rats. Furthermore, after AK-7 (a selective Sirtuin 2 inhibitor) was injected into the substantia nigra at postnatal 540 days and 570 days (5 μg/side per day), striatal dopamine depletion was signiifcant-ly diminished and behavior abnormality was improved in aging rats with neonatal iron intake. Experimental ifndings suggest that increased neonatal iron intake may result in Parkinson’s dis-ease-like neurochemical and behavioral deifcits with aging, and inhibition of Sirtuin 2 expression may be a neuroprotective measure in Parkinson’s disease.
机标关键词：dopaminergic neuronssubstantia nigra
资助基金：Funding(No.81171204,81171203,30772280,81200871, and 81200921)a grant from the Project of Shanghai Municipal Education Commission of China, (No.14YZ046)a grant from the Project of Shanghai Municipal Health and Family Planning Commission of China, (No.20134049)a grant from the Proj-ect of Shanghai Jiao Tong University of China, (No. YG2013MS22)a grant from the Projects of Shanghai Committee of Science and Technology of China, (No.11nm0503300 and 12XD1403800)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1917-1922 )
英文信息