Pretreatment with scutellaria baicalensis stem-leaf total lfavonoid protects against cerebral ischemia/reperfusion injur y in hippocampal neurons
Xiangyu Kong
Wei Kong
Guangxin Miao
Shumin Zhao
Meng Chen
Xiaoying Zheng
Jiangtao Bai
摘要：Previous experimental studies have shown that cerebral infarction can be effectively reduced following treatment with scutellaria baicalensis stem-leaf total lfavonoid (SSTF). However, the mechanism of action of SSTF as a preventive drug to treat cerebral infarction remains unclear. In this study, Sprague-Dawley rats were pretreated with 50, 100, 200 mg/kg SSTF via intragastric ad-ministration for 1 week prior to the establishment of focal cerebral ischemia/reperfusion injury. The results showed that pretreatment with SSTF effectively improved neurological function, re-duced brain water content and the permeability of blood vessels, ameliorated ischemia-induced morphology changes in hippocampal microvessels, down-regulated Fas and FasL protein expres-sion, elevated the activity of superoxide dismutase and glutathione peroxidase, and decreased malondialdehyde content. In contrast to low-dose SSTF pretreatment, the above changes were most obvious after pretreatment with moderate-and high-doses of SSTF. Experimental ifndings indicate that SSTF pretreatment can exert protective effects on the brain against cerebral isch-emia/reperfusion injury. The underlying mechanisms may involve reducing brain water content, increasing microvascular recanalization, inhibiting the apoptosis of hippocampal neurons, and attenuating free radical damage.
机标关键词：focal cerebral ischemiascutellaria baicalensiscerebral infarctionwater contentglutathione peroxidasesuperoxide dismutaseexperimental studiesmechanism of action
资助基金：This study was supported by the grants from Hebei Provincial Science and Technology Department, (No.07276101D-46)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2066-2073 )
英文信息