Puerarin protects brain tissue against cerebral ischemia/reperfusion injur y by inhibiting the inlfammator y response
Feng Zhou
Liang Wang
Panpan Liu
Weiwei Hu
Xiangdong Zhu
Hong Shen
Yuanyuan Yao
摘要：Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral isch-emia/reperfusion injury, but its mechanism is unknown. Here, we established rat models of middle cerebral artery ischemia/reperfusion injury using the suture method. Puerarin (100 mg/kg) was administered intraperitoneally 30 minutes before middle cerebral artery occlusion and 8 hours after reperfusion. Twenty-four hours after reperfusion, we found that puerarin signiifcantly im-proved neurological deifcit, reduced infarct size and brain water content, and notably diminished the expression of Toll-like receptor-4, myeloid differentiation factor 88, nuclear factor kappa B and tumor necrosis factor-αin the ischemic region. These data indicate that puerarin exerts an anti-inlfammatory protective effect on brain tissue with ischemia/reperfusion damage by down-regulating the expression of multiple inlfammatory factors.
机标关键词：middle cerebral arterytraditional Chinese medicineneuroprotective effectdifferentiation factorwater content
资助基金：This study was supported by the Chinese Traditional Medical Science Foundation of Zhe-jiang Province in China, (No.2010ZA072)the Health Bureau Foundation of Zhejiang Province in China, (No.2012ZDA023)the Qianjiang Project of Zhejiang Science and Technology Bureau in China, (No.2010 R10073)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2074-2080 )