Angioplasty and stenting for severe vertebral artery oriifce stenosis:effects on cerebellar function remodeling veriifed by blood oxygen level-dependent functional magnetic resonance imaging
Bo Liu
Zhiwei Li
Peng Xie
摘要：Vertebral artery oriifce stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood lfow and perfusion in the posterior circulation after inter-ventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso-nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery oriifce stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat-ment only. The intervention group received vertebral artery oriifce angioplasty and stenting+identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent function-al magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery oriifce stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.
机标关键词：interventional therapymagnetic resonance imagingneuroprotective effectsChinese patientsdrug treatmentblood supply
资助基金：This study was supported by the Natural Science Foundation of Yongchuan District of Chongqing in China, (No. Ycstc,2013nc8031)the Foundation of Chongqing Municipal Health Bureau in China, (No.2010-2-250)the Foundation of Chongqing Health and Family Planning Com-mission in China, (No.20143001)the Soft Science Foundation of Yongchuan District of Chongqing in China, (No. Ycstc,2011BE5004)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 2095-2101 )