A novel artiifcial nerve graft for repairing long-distance sciatic nerve defects:a self-assembling peptide nanoifber scaffold-containing poly(lactic-co-glycolic acid) conduit
Xianghai Wang
Mengjie Pan
Jinkun Wen
Yinjuan Tang
Audra D Hamilton
Yuanyuan Li
Changhui Qian
Zhongying Liu
Wutian Wu
Jiasong Guo
摘要：In this study, we developed a novel artiifcial nerve graft termed self-assembling peptide nanoifber scaffold (SAPNS)-containing poly(lactic-co-glycolic acid) (PLGA) conduit (SPC) and used it to bridge a 10-mm-long sciatic nerve defect in the rat. Retrograde tracing, behavioral testing and histomorphometric analyses showed that compared with the empty PLGA conduit implanta-tion group, the SPC implantation group had a larger number of growing and extending axons, a markedly increased diameter of regenerated axons and a greater thickness of the myelin sheath in the conduit. Furthermore, there was an increase in the size of the neuromuscular junction and myoifber diameter in the target muscle. These ifndings suggest that the novel artiifcial SPC nerve graft can promote axonal regeneration and remyelination in the transected peripheral nerve and can be used for repairing peripheral nerve injury.
机标关键词：sciatic nerveperipheral nerve injurynerve graftaxonal regenerationmyelin sheath
资助基金：a grant from the National Key Basic Research Program of China, (No.2014CB542202 and 2014CB542205)the National Natural Science Foundation of China, (No.30973095&81371354)a grant from Science and Technology Project of Guangzhou, in China, (No.12C32121609)the Natural Science Foundation of Guangdong Province of China, (No. S2013010014697 to Guo JS and Hong Kong SCI Fund to Wu WT)
论文发表日期：2014-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2132-2141 )
英文信息